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Medical Terminology: Roots, Prefixes, and Combining Forms the CCMA Exam Tests

2026-09-01By ExamReady Team

Why medical terminology matters for the CCMA

Every clinical question on the NHA CCMA exam uses medical terminology — body system names, symptom descriptors, diagnostic terms, abbreviations. A candidate who can decode a word into its parts (prefix, root, suffix) can answer questions about diseases, procedures, and medications even when the specific term is unfamiliar. Conversely, a candidate who memorizes words as wholes has to learn every term separately and runs out of time on the exam. This post covers the word parts you must know, the body-system terminology the exam tests, and the abbreviations every CCMA must recognize.

How medical terms are built

A medical term is composed of up to three parts:

  • Prefix — at the beginning of the word. Modifies the meaning. Often indicates location, time, quantity, or negation.
  • Root — the central meaning of the word. Usually refers to an organ, tissue, or condition. A term may have two roots (e.g., gastr + enter + ology).
  • Suffix — at the end of the word. Often indicates the procedure, condition, disease, or specialty.
  • Combining vowel — usually an "o" — added between roots or between a root and a suffix that begins with a consonant, to make the word pronounceable.

When you encounter an unfamiliar term, break it into parts:

  • Gastritisgastr (stomach) + -itis (inflammation) = inflammation of the stomach
  • Hepatomegalyhepat (liver) + -o- (combining vowel) + -megaly (enlargement) = enlargement of the liver
  • Endocarditisendo- (within) + card (heart) + -itis (inflammation) = inflammation of the inner lining of the heart

Prefixes the exam tests

Location and direction

  • Anter/o — front (anterior = toward the front)
  • Poster/o — back (posterior = toward the back)
  • Medi/o — middle (medial = toward the midline)
  • Later/o — side (lateral = away from the midline)
  • Super/o — above (superior = above)
  • Infer/o — below (inferior = below)
  • Proxim/o — near (proximal = closer to the point of attachment)
  • Dist/o — far (distal = farther from the point of attachment)
  • Peri- — around (pericardial = around the heart)
  • Circum- — around (circumduction = circular movement)
  • Endo- — within (endoscopy = looking within)
  • Exo- — outside (exocrine = secreting outward)
  • Trans- — across (transdermal = across the skin)
  • Inter- — between (intercostal = between the ribs)
  • Intra- — within (intravenous = within the vein)
  • Retro- — behind or backward (retroperitoneal = behind the peritoneum)
  • Supra- — above (suprapubic = above the pubic bone)
  • Sub- — below or under (subcutaneous = under the skin)
  • Bi- — two (bilateral = two sides)
  • Uni- — one (unilateral = one side)
  • Ad- — toward (adduction = movement toward the midline)

Quantity, degree, and negation

  • Hyper- — excessive (hypertension = excessive pressure)
  • Hypo- — deficient (hypothyroidism = deficient thyroid function)
  • Tachy- — fast (tachycardia = fast heart rate)
  • Brady- — slow (bradycardia = slow heart rate)
  • A-/An- — without (anemia = without blood; asymptomatic = without symptoms)
  • Dys- — difficult, painful (dyspnea = difficulty breathing)
  • Mal- — bad (malnutrition = bad nutrition)
  • Poly- — many (polyuria = excessive urine)
  • Olig/o — few (oliguria = scant urine)
  • Nulli- — none (nulliparous = no births)
  • Pre- — before (prenatal = before birth)
  • Post- — after (postoperative = after surgery)
  • Neo- — new (neoplasm = new growth)
  • Re- — again (relapse = falling ill again)
  • Co-/Con-/Com- — with, together (congenital = born with)

Suffixes the exam tests

Conditions and diseases

  • -itis — inflammation (bronchitis, dermatitis, phlebitis)
  • -osis — condition, often abnormal (cyanosis, thrombosis)
  • -iasis — condition produced by something (cholelithiasis = condition of having gallstones)
  • -emia — blood condition (anemia, ischemia, septicemia)
  • -pathy — disease (neuropathy, cardiomyopathy)
  • -megaly — enlargement (hepatomegaly, splenomegaly)
  • -malacia — softening (osteomalacia)
  • -sclerosis — hardening (atherosclerosis)
  • -stenosis — narrowing (spinal stenosis, aortic stenosis)
  • -spasm — involuntary contraction (bronchospasm)
  • -plegia — paralysis (hemiplegia, paraplegia)
  • -rrhage/-rrhagia — excessive flow (hemorrhage, menorrhagia)
  • -rrhea — discharge, flow (diarrhea, otorrhea)
  • -rrhexis — rupture (amniorrhexis)
  • -lysis — destruction or breakdown (hemolysis)
  • -cele — hernia, protrusion (rectocele, cystocele)
  • -ptosis — prolapse, drooping (blepharoptosis)
  • -somnia — sleep (insomnia)
  • -phobia — fear (claustrophobia)
  • -dynia/-algia — pain (arthralgia, otodynia)

Procedures and specialties

  • -ectomy — removal (appendectomy, tonsillectomy)
  • -tomy — incision into (tracheotomy)
  • -stomy — creation of an opening (colostomy, tracheostomy)
  • -plasty — surgical repair (rhinoplasty, valvuloplasty)
  • -scopy — visual examination (colonoscopy, bronchoscopy)
  • -scope — instrument for visual examination (laryngoscope)
  • -graphy — recording (electrocardiography, mammography)
  • -gram — the recording or image (electrocardiogram, mammogram)
  • -graph — the recording instrument (electrocardiograph)
  • -ology — study of (cardiology, neurology)
  • -ologist — specialist (cardiologist, neurologist)
  • -therapy — treatment (chemotherapy, radiation therapy)
  • -meter — measuring instrument (spirometer, sphygmomanometer)
  • -metry — measurement (spirometry)
  • -centesis — surgical puncture to remove fluid (thoracentesis, amniocentesis)
  • -desis — binding or fusion (arthrodesis)
  • -pexy — fixation or suspension (nephropexy)
  • -tripsy — crushing (lithotripsy)

Body-system roots

Cardiovascular

  • Cardi/o — heart (cardiology, pericardium)
  • Vas/o, Vascul/o — vessel (vasoconstriction, vasculitis)
  • Arteri/o — artery (arteriosclerosis)
  • Phleb/o, Ven/o — vein (phlebitis, venipuncture)
  • Angi/o — vessel (angioplasty, angiography)
  • Aort/o — aorta (aortic stenosis)
  • Valvul/o, Valv/o — valve (valvuloplasty)
  • Thromb/o — clot (thrombosis, thrombocytopenia)
  • Embol/o — embolus (embolism)
  • Isch/o — to hold back (ischemia)

Respiratory

  • Pulmon/o, Pneum/o, Pneumon/o — lung (pulmonary, pneumonitis)
  • Bronch/o, Bronchi/o — bronchus (bronchitis, bronchoscopy)
  • Trache/o — trachea (tracheostomy)
  • Laryng/o — larynx (laryngitis)
  • Pharyng/o — pharynx (pharyngitis)
  • Rhin/o — nose (rhinitis, rhinorrhea)
  • Sinus/o — sinus (sinusitis)
  • Pleur/o — pleura (pleurisy)
  • Ox/o, Ox/i — oxygen (hypoxia)
  • Capn/o — carbon dioxide (hypercapnia)
  • Spir/o — breathing (spirometry)
  • -pnea — breathing (dyspnea, apnea, tachypnea)

Digestive

  • Gastr/o — stomach (gastritis, gastrectomy)
  • Enter/o — intestine (enteritis, gastroenterology)
  • Duoden/o — duodenum (duodenal ulcer)
  • Jejun/o — jejunum
  • Ile/o — ileum (ileostomy)
  • Col/o, Colon/o — colon (colitis, colonoscopy)
  • Rect/o — rectum (rectocele)
  • An/o — anus (anorectal)
  • Proct/o — rectum or anus (proctoscopy)
  • Hepat/o — liver (hepatitis, hepatomegaly)
  • Cholecyst/o — gallbladder (cholecystectomy)
  • Chol/e — bile or gall (cholelithiasis, cholecystitis)
  • Pancreat/o — pancreas (pancreatitis)
  • Sial/o — saliva (sialadenitis)

Urinary

  • Ren/o, Nephro — kidney (renal, nephrectomy, nephritis)
  • Ureter/o — ureter (ureteral)
  • Cyst/o, Vesic/o — bladder (cystitis, cystoscopy)
  • Urethr/o — urethra (urethritis)
  • Ur/o, Uria — urine (urinalysis, dysuria, polyuria)
  • Lith/o — stone or calculus (nephrolithiasis, lithotripsy)
  • -uresis — urination (diuresis, enuresis)

Reproductive

  • Gynec/o — female (gynecology)
  • Hyster/o, Metr/o, Uter/o — uterus (hysterectomy, endometrium)
  • Oophor/o, Ovari/o — ovary (oophorectomy)
  • Salping/o — fallopian tube (salpingitis)
  • Mamm/o, Mast/o — breast (mammogram, mastectomy)
  • Colp/o, Vagin/o — vagina (colposcopy, vaginitis)
  • Men/o, Mens/o — menstruation (menopause, menorrhagia)
  • Andr/o — male (androgen)
  • Test/o, Testicul/o, Orch/o, Orchid/o — testis (testosterone, orchitis)
  • Prostat/o — prostate (prostatitis, prostatectomy)
  • Balan/o — glans penis (balanitis)

Musculoskeletal

  • Oste/o — bone (osteoporosis, osteomyelitis)
  • Chondr/o — cartilage (chondromalacia)
  • Myel/o — bone marrow or spinal cord (myeloma, myelogram)
  • Arthr/o — joint (arthritis, arthroscopy)
  • Synov/o — synovial membrane (synovitis)
  • My/o, Myos/o, Muscul/o — muscle (myalgia, myositis)
  • Tend/o, Tendin/o, Ten/o — tendon (tendinitis)
  • Ligament/o — ligament
  • Burs/o — bursa (bursitis)
  • Fasci/o — fascia (fasciitis)
  • -desis — fusion (arthrodesis)
  • -lysis — release or breakdown
  • -clasis — break or fracture

Integumentary

  • Derm/o, Dermat/o, Cutane/o — skin (dermatitis, subcutaneous)
  • Epiderm/o — epidermis
  • Pachy- — thick (pachyderma)
  • Leuk/o — white (leukoderma)
  • Erythr/o — red (erythema)
  • Melan/o — black or melanin (melanoma, melanocyte)
  • Xer/o — dry (xeroderma)
  • Hidr/o — sweat (hyperhidrosis)
  • Seb/o — sebum (seborrhea)
  • Pil/o, Trich/o — hair (pilonidal, trichosis)
  • Onych/o, Ungul/o — nail (onychomycosis)
  • -plakia — patch (leukoplakia)

Nervous

  • Neur/o — nerve (neuritis, neuropathy)
  • Encephal/o — brain (encephalitis, encephalopathy)
  • Mening/o, Meningi/o — meninges (meningitis)
  • Myel/o — spinal cord (myelomeningocele)
  • Gli/o — glial cell (glioma)
  • Cephal/o — head (cephalgia, hydrocephalus)
  • Crani/o — skull (craniotomy, craniectomy)
  • -lexia — reading (dyslexia)
  • -phasia — speech (aphasia)
  • -plegia — paralysis (hemiplegia)
  • -esthesia — sensation (anesthesia, paresthesia)

Common abbreviations every CCMA must know

The Joint Commission publishes an official "Do Not Use" list of abbreviations that are unsafe in clinical practice (e.g., "U" for units, "q.d." for daily, "MS" or "MSO4" for morphine sulfate, "IU" for international units, "cc" for cubic centimeter). The exam tests this list. Use the long form:

  • "units" not "U"
  • "daily" not "q.d."
  • "morphine sulfate" not "MS" or "MSO4"
  • "international units" not "IU"
  • "milliliter" not "cc"

Common abbreviations the exam uses freely:

  • a.c. — before meals (ante cibum)
  • p.c. — after meals (post cibum)
  • q.h. — every hour (quaque hora)
  • q.i.d. — four times a day
  • t.i.d. — three times a day
  • b.i.d. — twice a day
  • q.d. — every day (avoid per Joint Commission)
  • q.o.d. — every other day
  • p.r.n. — as needed (pro re nata)
  • s.l. — sublingual
  • p.o. — by mouth (per os)
  • i.m. — intramuscular
  • i.v. — intravenous
  • s.c. or sub-q — subcutaneous
  • i.d. — intradermal
  • h.s. — at bedtime (hora somni)
  • N.P.O. — nothing by mouth (nil per os)
  • D/C — discharge or discontinue
  • Hx — history
  • Dx — diagnosis
  • Tx — treatment
  • Rx — prescription
  • c/o — complains of
  • s/p — status post
  • r/o — rule out
  • CPK, CBC, BMP, CMP — common lab panels
  • BP, HR, RR, T, SpO2 — vital signs

The exam's favorite terminology questions

Question type 1: "A patient is diagnosed with cholelithiasis. Which organ is involved?" — Answer: gallbladder. Chole- means bile or gall, -lithiasis means stone condition.

Question type 2: "A procedure is described as a nephrectomy. What is being performed?" — Answer: removal of a kidney. Nephr- means kidney, -ectomy means removal.

Question type 3: "What does -rrhagia mean?" — Answer: excessive flow or bursting forth (as in hemorrhage).

Question type 4: "A CCMA sees the order 'q.i.d. AC and HS.' How should the medication be taken?" — Answer: four times a day, before meals and at bedtime.

A practical closing note

Terminology is the easiest section of the exam to improve, because it is memorizable in blocks. Spend an hour learning the prefixes and suffixes — they apply across every system. Then learn the body-system roots in clusters (cardiovascular, respiratory, digestive). The exam rewards the candidate who can break a term into parts; practice this actively. When you encounter an unfamiliar term, write it out and parse it. After a few weeks of practice, you will recognize terms you have never seen before.

For terminology practice with body-system grouping and the Joint Commission "Do Not Use" list, visit the ExamReady CCMA prep site. Every question maps to the NHA CCMA content outline.